After working at every level of the organization, Güler Sabancı has been the Chair of Sabancı Holding for 21 years, one of the leading and most reputable business groups in Türkiye, and Chair of the Board of Trustees of the Sabancı Foundation, the leading private foundation in Türkiye. Sabancı is the Founding Chair of Sabancı University and also acts as Chair of the Sakıp Sabancı Museum. Güler Sabancı is among "World's 100 Most Powerful Women" lists by international media organizations.

Besides being an effective industrialist, prominent business figure, and renowned art- enthusiast, she has also been accepted as one of the most influential women in the region for her work on gender equality and social development. Her remarkable success has been recognized internationally with numerous awards, including the David Rockefeller Bridging Leadership Award, the Clinton Global Citizen Award, the Raymond Georis Prize for Innovative Philanthropy, and the European School of Management Responsible Leadership Award. In recognition of her contributions to sustainability, Güler Sabancı was honored with the European Sustainability Award – Prix Film4climate at the 36th European Film Awards organized by the European Film Academy in 2023 for the sustainability-focused efforts of the Sabancı Foundation Short Film Competition.

The first female member of the European Round Table for Industry, she sits on the MIT Energy Initiative’s External Advisory Board. She is also a member of The Trilateral Commission and TÜSİAD. Additionally, in 2024, during the 100th anniversary of diplomatic relations between Japan and Türkiye, she became the first Turkish woman to be honored with one of Japan’s most prestigious decorations, the "Order of the Rising Sun, Gold Rays with Neck Ribbon."